基本情況
陳亞檞，男，山西大同人，中國共產黨黨員。現任五邑大學藥學與食品工程學院專任教師。
聯系方式
地址：廣東省江門市蓬江區東成村22號五邑大學藥學與食品工程學院
郵編：529020
郵箱：Yajie-Wuyi@yeah.net
工作經歷
2020年7月至今，五邑大學，生物科技與大健康學院，碩士生導師
2019年11月至2020年6月，日本山梨大學醫學部，助理教授
教育及學習經歷
2015年10月-2019年9月，日本山梨大學醫學部，博士
2012年9月-2015年7月，中國科學院城市環境研究生，碩士
2008年9月-2012年6月，華僑大學，本科
主要研究方向
高脂血癥，動脈硬化，人源疾病大動物模型開發
發表學術論文
1.Chen YJ*, Waqar AB*, Nishijima K, Ning B, Kitajima S, Matsuhisa F, Chen L, Liu EQ, Zhang J, Chen YE, Liang JY and Fan JL: Macrophage-derived MMP-9 enhanced the vascular calcification and progression of atherosclerotic lesions in transgenic rabbits.J Cell Mol Med.2020;
2.Chen YJ*, Waqar AB*, Yan HZ, Wang YL, Liang JY, Fan JL. Renovascular hypertension aggravates atherosclerosis in cholesterol-fed rabbits.J Vasc Rea. 2019;56:28-38
3.Yuan TT, Zhong Y, Wang YG, Zhang T, Lu R, Zhou MY, Lu YY, Yan KN,Chen YJ, Hu ZH, Liang JY, Fan JL, Cheng Y. Generation of hyperlipidemic rabbit models using multiple sgrnas targeted crispr/cas9 gene editing system.Lipids Health Dis. 2019;18
4.Ning B*,Chen YJ, Waqar AB*, Yan HZ, Shiomi M, Zhang JF, Chen YE, Wang YL, Itabe H, Liang JY, Fan JL. Hypertension enhances advanced atherosclerosis and induces cardiac death in watanabe heritable hyperlipidemic rabbits.Am J Pathol. 2018;188:2936-2947
5.Fan JL,Chen YJ, Yan HZ, Niimi M, Wang YL, Liang JY. Principles and applications of rabbit models for atherosclerosis research.J Atheroscler Thromb. 2018;25:213-220
6.Fan JL,Chen YJ, Yan HZ, Liu BN, Wang YL, Zhang JF, Chen YE, Liu EQ, Liang JY. Genomic and transcriptomic analysis of hypercholesterolemic rabbits: Progress and perspectives.Int J Mol Sci. 2018;19
7.Lu R, Yuan TT, Wang YG, Zhang T, Yuan YG, Wu DJ, Zhou MY, He ZY, Lu YY,Chen YJ, Fan JL, Liang JY, Cheng Y. Spontaneous severe hypercholesterolemia and atherosclerosis lesions in rabbits with deficiency of low-density lipoprotein receptor (ldlr) on exon 7.Ebiomedicine. 2018;36:29-38
8.Wang C, Nishijima K, Kitajima S, Niimi M, Yan HZ,Chen YJ, Ning B, Matsuhisa F, Liu EQ, Zhang JF, Chen YE, Fan JL. Increased hepatic expression of endothelial lipase inhibits cholesterol diet-induced hypercholesterolemia and atherosclerosis in transgenic rabbits.Arterioscl Throm Vas. 2017;37:1282-
9.Huang QS*,Chen YJ*, Lin LF, Liu YY, Chi YL, Lin Y, Ye GZ, Zhu HM, Dong SJ. Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of oryzias melastigma under environmentally relevant doses.Sci Total Environ. 2017;595:752-758
10.Huang QS*,Chen YJ*, Chen QH, Zhang HT, Lin Y, Zhu MB, Dong SJ. Dioxin-like rather than non-dioxin-like pcbs promote the development of endometriosis through stimulation of endocrine-inflammation interactions.Arch Toxicol. 2017;91:1915-1924
11.Ye GZ*,Chen YJ*, Wang HO*, Ye T, Lin Y, Huang QS, Chi YL, Dong SJ. Metabolomics approach reveals metabolic disorders and potential biomarkers associated with the developmental toxicity of tetrabromobisphenol a and tetrachlorobisphenol a.Sci Rep-Uk. 2016;6
12.Ye T, Kang M, Huang QS, Fang C,Chen YJ, Liu LP, Dong SJ. Accumulation of di(2-ethylhexyl) phthalate causes endocrine-disruptive effects in marine medaka (oryzias melastigma) embryos.Environ Toxicol. 2016;31:116-127
13.Li S, Wang YN, Niimi MB, Ning B,Chen YJ, Kang DD, Waqar AB, Wang ZY, Yu Q, Liu EQ, Zhang JF, Shiomi M, Chen YE, Fan JL. Angiotensin ii destabilizes coronary plaques in watanabe heritable hyperlipidemic rabbits.Arterioscl Throm Vas. 2016;36:810-816
14.Chen YJ, Huang QS, Chen QH, Lin Y, Sun X, Zhang HT, Zhu MB, Dong SJ. The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells.Toxicol in Vitro. 2015;29:308-313
15.Huang QS*,Chen YJ*, Chi YL, Lin Y, Zhang HT, Fang C, Dong SJ. Immunotoxic effects of perfluorooctane sulfonate and di(2-ethylhexyl) phthalate on the marine fish oryzias melastigma.Fish Shellfish Immun. 2015;44:302-306
16.Lin Y, Min LL, Huang QS,Chen YJ*, Fang C, Sun X, Dong SJ. The combined effects of dehp and pcbs on phospholipase in the livers of mice.Environ Toxicol. 2015;30:197-204
17.Sun X, Lin Y, Huang QS, Shi JP, Qiu L, Kang M,Chen YJ, Fang C, Ye T, Dong SJ. Di(2-ethylhexyl) phthalate-induced apoptosis in rat ins-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection.J Cell Mol Med. 2015;19:581-594
18.Wei J, Sun X,Chen YJ, Li YY, Song LQ, Zhou Z, Xu B, Lin Y, Xu SQ. Perinatal exposure to bisphenol a exacerbates nonalcoholic steatohepatitis-like phenotype in male rat offspring fed on a high-fat diet.J Endocrinol. 2014;222:313-325
19.Ye T, Kang M, Huang QS, Fang C,Chen YJ, Shen HQ, Dong SJ. Exposure to dehp and mehp from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (oryzias melastigma).Aquat Toxicol. 2014;146:115-126
20.Fang C, Huang Q, Ye T,Chen YJ, Liu L, Kang M, Lin Y, Shen HQ, Dong SJ. Embryonic exposure to pfos induces immunosuppression in the fish larvae of marine medaka.Ecotox Environ Safe. 2013;92:104-111
21.Huang QS, Fang C,Chen YJ, Wu X, Ye T, Lin Y, Dong SJ. Embryonic exposure to low concentration of bisphenol a affects the development of oryzias melastigma larvae.Environ Sci Pollut R. 2011;19:2506-2514
獲獎及榮譽
1. Young Research Investigator Award for 27thJapan Atherosclerosis Society, July, 2019, Japan
2. The Kato Memorial Bioscience Grant for International Research Fellowship, April, 2019, Japan
3. Travel Grant for the 18thInternational Symposium on Atherosclerosis, ISA Scientific Program Committee, March, 2018, Canada
4. Special Scholarship for Oversea Students, Yamanashi University, 2015-2018, Japan
5.留學基金委設立的優秀自費留學生獎, 2017,中國
6. 研究生國家獎學金，2014，中國
