基本情況
朱茂碧，女，海南人，中共黨員，江門市二級人才。現任五邑大學藥學與食品工程學院專任教師。主持五邑大學五邑大學高層次人才科研啟動經費、省市級項目共計3項，在研總經費超過100萬。參與國家自然科學基金面上項目、重點研發項目、廣東省教育廳創新團隊及重點領域專項等若干項。已發表SCI論文十多篇，其中第一作者及通訊作者文章5篇。目前依托華南生物醫藥大動物模型研究院及廣東省醫學大動物重點實驗室開展研究工作，研究方向為利用干細胞及類器官技術研究婦產科相關疾病發生機制，生殖健康、基因編輯動物模型的建立等。
聯系方式
地址：廣東省江門市蓬江區東成村22號 五邑大學藥學與食品工程學院
郵編：529020
郵箱：maobizhu@163.com
工作經歷
2020年7月至今，五邑大學，藥學與食品工程學院，碩士生導師
教育及學習經歷
2016年4月-2020年3月 日本國立山梨大學，醫學工學綜合研究部，博士
2012年9月-2015年6月 廈門大學，醫學院，碩士
2006年9月-2011年7月 廈門大學，醫學院，學士
主要研究方向
利用干細胞及類器官技術研究婦產科相關疾病發生機制，生殖健康、基因編輯動物模型的建立等
發表學術論文
1. Chen, Y.; Zhang, S.; Sun, Y.; Zou, J.; Qiu, X.; Xi, H.; Xu, Y.; Li, Y.; Chen, B.; Fan, J.; Zhu, M. Bisphenol A impairs oocyte maturation by dysfunction of cumulus cells. Theriogenology 2025, 233, 139-146, doi:10.1016/j.theriogenology.2024.11.023. （通訊作者）
2. Wang, N.; Yang, H.; Chen, Y.; Wang, H.; Wang, C.; Fan, J.; Chen, Y.; Li, Y.; Zhu, M. Formononetin promotes porcine oocytes maturation and improves embryonic development by reducing oxidative stress. Front Cell Dev Biol 2024, 12, 1520429, doi:10.3389/fcell.2024.1520429. （通訊作者）
3. Zhu, M.; Wang, N.; Wang, S.; Wang, Y.; Yang, X.; Fan, J.; Chen, Y. Effects of Follicular Fluid on Physiological Characteristics and Differentiation of Fallopian Tube Epithelial Cells Implicating for Ovarian Cancer Pathogenesis. Int. J. Mol. Sci. 2023, 24, 10154.
4. Zhu, M., S. Takeda, and T. Iwano, Natural Herbal Estrogen-Mimetics (Phytoestrogens) Promote the Differentiation of Fallopian Tube Epithelium into Multi-Ciliated Cells via Estrogen Receptor Beta. Molecules, 2021. 26(3).
5. Zhu, M.; Iwano, T.; Takeda, S. Fallopian Tube Basal Stem Cells Reproducing the Epithelial Sheets In Vitro—Stem Cell of Fallopian Epithelium. Biomolecules 2020, 10, 1270.
6. Zhu, M., Iwano, T., and Takeda, S. (2019). Estrogen and EGFR Pathways Regulate Notch Signaling in Opposing Directions for Multi-Ciliogenesis in the Fallopian Tube. Cells 2019, 8, 933.
7. Dai, S., Zhu, M., Wu, R., Lin, D., Huang, Z., Ren, L., Huang, S., Cheng, L., and Chen, Q. (2019). Lipoxin A4 Suppresses IL-1beta-Induced Cyclooxygenase-2 Expression Through Inhibition of p38 MAPK Activation in Endometriosis. Reprod Sci, 1933719119828115. (Co-first author)
8. Wang, J.; Li, Y.-H.; Liu, R.-P.; Wang, X.-Q.; Zhu, M.-B.; Cui, X.-S.; Dai, Z.; Kim, N.-H.; Xu, Y.-N. Supplementation with Eupatilin during In Vitro Maturation Improves Porcine Oocyte Developmental Competence by Regulating Oxidative Stress and Endoplasmic Reticulum Stress. Animals 2024, 14, 449.
9. Chen, Y., X. Yang, S. Kitajima, L. Quan, Y. Wang, M. Zhu, E. Liu, L. Lai, H. Yan and J. Fan, Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. Front Cell Dev Biol, 2022. 10: p. 1097137.
10. Chen, Y., X. Yang, S. Kitajima, L. Quan, Y. Wang, M. Zhu, E. Liu, L. Lai, H. Yan and J. Fan, Macrophage elastase derived from adventitial macrophages modulates aortic remodeling. Front Cell Dev Biol, 2022. 10: p. 1097137.
11. Huang, Q., Chen, Y., Chen, Q., Zhang, H., Lin, Y., Zhu, M., and Dong, S. (2017). Dioxin-like rather than non-dioxin-like PCBs promote the development of endometriosis through stimulation of endocrine-inflammation interactions. Archives of toxicology 91, 1915-1924.
12. Chen, Y., Huang, Q., Chen, Q., Lin, Y., Sun, X., Zhang, H., Zhu, M., and Dong, S. (2015). The inflammation and estrogen metabolism impacts of polychlorinated biphenyls on endometrial cancer cells. Toxicology in vitro: an international journal published in association with BIBRA 29, 308-313.
13. Wu, R., Zhou, W., Chen, S., Shi, Y., Su, L., Zhu, M., and Chen, Q. (2014). Lipoxin A4 suppresses the development of endometriosis in an ALX receptor-dependent manner via the p38 MAPK pathway. British journal of pharmacology 171, 4927-4940.
14. Chen, S., Wu, R.F., Su, L., Zhou, W.D., Zhu, M.B., and Chen, Q.H. (2014). Lipoxin A4 regulates expression of the estrogen receptor and inhibits 17beta-estradiol induced p38 mitogen-activated protein kinase phosphorylation in human endometriotic stromal cells. Fertility and sterility 102, 264-271.
15. Shen, Y.T., Song, Y.Q., He, X.Q., Zhang, F., Huang, X., Liu, Y., Ding, L., Xu, L., Zhu, M.B., Hu, W.F., et al. (2014). Triphenyltin chloride induces spindle microtubule depolymerisation and inhibits meiotic maturation in mouse oocytes. Reprod Fertil Dev 26, 1084-1093.
16. Liu, Y., He, X.Q., Huang, X., Ding, L., Xu, L., Shen, Y.T., Zhang, F., Zhu, M.B., Xu, B.H., Qi, Z.Q., et al. (2013). Resveratrol protects mouse oocytes from methylglyoxal-induced oxidative damage. PLoS One 8, e77960.
參加學術會議及論文
(1) Estrogen promotes the fallopian tube epithelial multi-ciliogenesis through estrogen receptor β, Japan Society for Cell Biology,日本東京(會議報告)
(2) The Role of Estrogen and Notch Signal in Porcine Fallopian Tube Epithelium Differentiation,日本解剖學會年會,日本東京(會議報告)
(3) Suppression of Notch signal by estrogen and EGFR pathway facilitates motile ciliogenesis in fallopian tube epithelial cells,日本纖毛學會,日本山梨(會議報告)
(4) Estrogen regulates ciliogenesis through estrogen receptorβin porcine fallopian tube,日本解剖學會年會,日本長崎(會議報告)
申請及授權專利
1、一種體外豬來源的輸卵管上皮細胞類組織培養方法，發明人：朱茂碧; 王娜; 王莎; 陳亞檞; 范江霖; 王瑤; 楊夏雯，申請號：202310019244.3，申請時間：2023年01月06日，授權單位：五邑大學，發明專利
2、一種促進輸卵管上皮纖毛細胞形成的添加劑及其應用，發明人：朱茂碧,王莎,王娜,襲昊曈,張雙,鄒家倫,范江霖,陳亞檞，申請號：202310412768.9，申請日：2023 年04 月17 日，授權單位：五邑大學，發明專利
3、一種誘導原代輸卵管上皮細胞定向分化為纖毛細胞的方法，發明人：朱茂碧,王莎,王娜,襲昊曈,張雙,鄒家倫,范江霖,陳亞檞，申請號：2023104133073，申請日：2023 年04 月17 日，授權單位：五邑大學，發明專利
獲獎及榮譽
2017-2020中國留學基金委公派留學獎學金
